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National Challenges, Regional Solutions CME initiative launches on CVspectrum!

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Evidence suggests that the greatest barrier to long-term risk-reduction following an acute coronary event is patient adherence. Data from the American Heart Association (AHA) suggests that 18% of men and 23% of women over the age of 40 years will die within 1 year of an initial myocardial infarction. Meanwhile, approximately 20% of ACS patients are rehospitalized within 1 year.

National Challenges, Regional Solutions: Strategies for Improving the Long-Term Management of Patients Following Acute Coronary Events is a novel educational program that focuses on post-PCI risk management and improving nonadherence rates in post-ACS patients within the critical first year and beyond.

NEW! The Risk Reporter eNewsletter series is coming to CVspectrum

COMING SOON!The Risk Reporter eNewsletter series from National Challenges, Regional Solutions: Strategies for Improving the Long-Term Management of Patients Following Acute Coronary Events. The Risk Reporter will address barriers to optimal post-ACS outcomes and offer regional perspectives on evidence-based clinical strategies that can be implemented at the point of care.

In Editorials

Interview with Dr. Paul Thompson on the Role of Coenzyme Q10 (CoQ10) in Statin-Associated Myopathy

Paul D. Thompson, MD

Although serious statin-associated myopathy is rare, muscle-related complaints are generally held to be the most common and clinically significant adverse effects of statin therapy. The mechanism by which statins may affect muscle is unknown, and a number of explanations have been proposed. One theory that has attracted wide interest relates statin-associated muscle complaints to depletion of coenzyme Q10 (CoQ10). The role of CoQ10 in statin-associated myopathy is the subject of a recently published systematic review by Leo Marcoff and APOLLO Steering Committee member Paul D. Thompson.¹ In this interview, Dr. Thompson discusses the prevalence of statin-related muscle complaints, theories about their causation, and the conclusions of his and Dr. Marcoff’s review of the evidence on the role of CoQ10.

In Q & A

Besides therapeutic lifestyle change, what treatment do you recommend for a patient at high risk for CAD but unable to take or tolerate a statin?
- APOLLO User

Clinical Pearl

Exercise

Weigh patients at every yearly visit and if their weight is up, even a little, get them on a daily exercise and weight loss program. It's easier to lose 2 pounds 50 times than 100 pounds once.

Paul D. Thompson, MD

Slide Library

Recent Atherosclerosis Reduction TrialsTreatment of Mixed Dyslipidemia With ER Niacin Combined With a Flushing Pathway Inhibitor

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In General Cardiology
More News >>>

Symptoms during exercise testing ‘unrelated to HF outcomes’
Monday, December 08, 2008 - In heart failure patients undergoing exercise testing, the degree of exercise intolerance is a better indicator of prognosis than the development of specific symptoms, UK researchers have shown.
Provisional T-stenting best for coronary bifurcation lesions
Monday, December 08, 2008 - Provisional T-stenting is superior to routine T-stenting in the treatment of coronary bifurcation lesions, a randomized study using sirolimus-eluting stents has demonstrated.
Higher SBPs linked to lower mortality in CHF
Monday, December 08, 2008 - Meta-analysis findings demonstrate an inverse relationship between systolic blood pressure levels and mortality in patients with chronic heart failure.

In Lipid Management
More News >>>

Choice of CVD risk calculator important for diabetes patients
Monday, December 08, 2008 - Using a non-diabetes-specific risk calculator for cardiovascular disease would deny a small but significant number of diabetes patients statin therapy under current UK National Institute for Health and Clinical Excellence guidelines, researchers report.
Elevated ApoM is not a risk factor for CAD
Monday, December 08, 2008 - Apolipoprotein M is not an independent risk factor but may be a useful biomarker for coronary artery disease, a Chinese case–control study has found.
High levels of sd-LDLs in Chinese stroke patients
Monday, December 08, 2008 - Results from a case–control study show increased levels of small, dense low-density lipoproteins in Chinese stroke patients compared with control individuals.

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Supported by educational grants from Abbott Laboratories, Daiichi-Sankyo, Inc., and Eli Lilly and Company.
Supported by an educational grant from Molecular Insight Pharmaceuticals, Inc.

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