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Lipid Management News

Featured Articles from the last 5 days

  • Plaque lipid location 'profoundly' alters rupture risk
    Thursday, October 20, 2005 - Indian scientists have demonstrated that blood vessel shape and the location of lipid plaque cores greatly influences plaque vulnerability and rupture risk.
  • Low adiponectin levels predict atherogenic lipid profile in FCH
    Tuesday, October 18, 2005 - Adiponectin levels are independently and significantly associated with the atherogenic lipid profile in patients with familial combined hyperlipidemia, Dutch clinicians report.
  • Low adiponectin levels predict atherogenic lipid profile in FCH
    Tuesday, October 18, 2005 - Adiponectin levels are independently and significantly associated with the atherogenic lipid profile in patients with familial combined hyperlipidemia, Dutch clinicians report.
  • Negative artery remodeling linked with LDL level
    Tuesday, October 18, 2005 - The negative coronary artery remodeling often seen in patients with diabetes is independently associated with levels of low-density lipoprotein cholesterol, study results published in the European Heart Journal show.
  • Serum amyloid A reduces lesion lipid content
    Friday, October 14, 2005 - Contrary to previous suggestions, Canadian clinicians have demonstrated that serum amyloid A peptides can prevent and reverse the formation of lipid-laden aortic lesions in mice genetically prone to atherosclerosis.
  • Very low LDL levels reduce post-ACS risk
    Friday, October 14, 2005 - Concerns over reducing levels of low-density lipoprotein cholesterol to very low levels with intensive statin therapy seem to be unwarranted, further findings from the PROVE-IT-TIMI 22 trial suggest.
  • ACS statin therapy should be ‘intense, immediate and continuous’
    Thursday, October 13, 2005 - An analysis of data from the PROVE-IT-TIMI 22 trial has led researchers to recommend that all patients with acute coronary syndromes should be given intensive statin therapy, starting in hospital and continuing for the long term, to maximize benefits.
  • Plaque lipid location 'profoundly' alters rupture risk
    Thursday, October 13, 2005 - Indian scientists have demonstrated that blood vessel shape and the location of lipid plaque cores greatly influences plaque vulnerability and rupture risk.
  • Serum amyloid A reduces lesion lipid content
    Friday, October 14, 2005 - Contrary to previous suggestions, Canadian clinicians have demonstrated that serum amyloid A peptides can prevent and reverse the formation of lipid-laden aortic lesions in mice genetically prone to atherosclerosis.
  • RLPs link metabolic syndrome and CVD
    Monday, October 03, 2005 - Researchers have shown that individuals with the metabolic syndrome have raised levels of remnant-like lipoprotein cholesterol particles, an abnormality they believe may explain the increased incidence of cardiovascular disease in those with the condition.
  • Obesity 'a critical issue' for young Koreans
    Friday, September 23, 2005 - The rising prevalence of obesity among young people in Korea is translating into a substantial increase in Type 2 diabetes, public health scientists have warned.
  • OxLDL unrelated to stenting outcomes
    Friday, September 23, 2005 - Circulating levels of oxidized low-density-lipoproteins are not associated with restenosis or other adverse events in patients who have undergone coronary stenting, German researchers have found.
  • Western diets 'may trigger prothrombotic state'
    Friday, September 23, 2005 - New research suggests that diets containing moderate amounts of fat - the so-called typical western diet - may play a larger role in cardiovascular disease than previously thought, merely through altering lipid levels.
  • No extra benefit from adding sterols to ezetimibe
    Thursday, September 22, 2005 - Consuming plant sterols in addition to ezetimibe offers no therapeutic benefit over ezetimibe alone in patients with mild hypercholesterolemia, Dutch researchers report this week.
  • Obesity is major CV risk determinant
    Thursday, September 22, 2005 - Obesity should be considered a major independent risk factor for cardiovascular mortality because it significantly increases the prevalence of related risk factors, notably high blood pressure, experts argue in the current issue of Hypertension.
  • Sympatholytic effect of simvastatin under scrutiny
    Thursday, September 22, 2005 - Simvastatin therapy may modulate the sympathetic response to stress, results of a prospective trial suggest.
  • CRP is 'missing link' between obesity and vascular inflammation
    Wednesday, September 21, 2005 - US researchers claim to have found the first link between obesity, inflammation, and vascular disease with the discovery that human fat cells produce C-reactive protein.
  • Fish oil reduces heart rate
    Wednesday, September 21, 2005 - Fish oil supplements reduce heart rate, a major risk factor for sudden death, results of a meta-analysis suggest.
  • Lipids 'not checked' in half of AMI patients
    Wednesday, September 21, 2005 - Flying in the face of current guidelines, new research has found that less than half of all patients admitted to hospital with acute myocardial infarction have their blood lipids tested.
  • Adiponectin strongly tied to hepatic lipase activity
    Tuesday, September 20, 2005 - German scientists have shown for the first time that low adiponectin levels are independently associated with increased hepatic lipase activity.
  • Statins 'may activate PPAR-a'
    Tuesday, September 20, 2005 - Findings from a small study support the theory that statins activate peroxisome proliferator-activated receptor-alpha, a finding that has implications for the management of dyslipidemia in patients with Type 2 diabetes.
  • Vascular abnormalities found in overweight teens
    Tuesday, September 20, 2005 - Children as young as 13 years show adverse changes in the arterial wall, reflecting the early metabolic consequences of being overweight, British researchers have found.
  • Bezafibrate delays diabetes onset
    Monday, September 19, 2005 - Bezafibrate therapy can prevent or delay the development of Type 2 diabetes in obese individuals, study findings indicate.
  • Graffiti 'makes you fat'
    Monday, September 19, 2005 - People who live in green, graffiti-free neighborhoods are more likely to be fit, active, and a healthy weight than those living in less pleasant surroundings, UK researchers have found.
  • Novel role for PPAR-a in cholesterol efflux
    Monday, September 19, 2005 - Research by European scientists has identified a novel role for peroxisome proliferator-activated receptor-alpha in regulating cholesterol trafficking in macrophages.
  • Alzheimer's beta amyloid activity 'mimics cholesterol oxidase'
    Friday, September 16, 2005 - Copper-mediated oxidation of cholesterol may be a pathogenic mechanism common to atherosclerosis and Alzheimer's disease, study findings show.
  • Bariatric surgery effective in CAD patients
    Friday, September 16, 2005 - Obese patients with coronary artery disease may effectively undergo bariatric surgery when other weight-loss options have failed, Mayo Clinic researchers report this week.
  • LPL polymorphism predicts restenosis risk
    Friday, September 16, 2005 - Dutch researchers have linked a polymorphism in the lipoprotein lipase gene to the likelihood of target-vessel revascularization following percutaneous coronary intervention.
  • Anti-inflammatory drugs show metabolic promise
    Thursday, September 15, 2005 - Anti-inflammatory drugs have the potential to prevent or treat hypertriglyceridemia and other components of the metabolic syndrome, US researchers say.
  • Statin benefits in heart failure elucidated
    Thursday, September 15, 2005 - US research has identified the mechanisms by which simvastatin exerts its beneficial effect in chronic heart failure, with the discovery that the drug inhibits central angiotensin II mechanisms and thereby the superoxide pathway.
  • TAFI: Part of the metabolic syndrome?
    Thursday, September 15, 2005 - In patients with diabetes, the co-existence of the metabolic syndrome and hypercholesterolemia acts synergistically to accelerate inflammation and impair fibrinolysis, study findings suggest.
  • Adiponectin predicts heart failure mortality
    Wednesday, September 14, 2005 - Adiponectin is an independent predictor of mortality in patients with chronic heart failure, probably reflecting its role as a marker for cachexia, Danish researchers have found.
  • Fat-rich diet boosts selective LDL uptake
    Wednesday, September 14, 2005 - Diets rich in saturated fats enhance selective uptake of low-density-lipoprotein cholesteryl esters into the arterial wall, and this mechanism may be a suitable for therapeutic intervention, animal study findings suggest.
  • Glitazones linked to lowered HDL-cholesterol
    Wednesday, September 14, 2005 - An analysis of the World Health Organization's drug monitoring database has revealed a disproportionately high rate of lowered high-density-lipoprotein cholesterol levels in patients taking thiazolidinediones.
  • Enzyme linked to diabetes lipid levels
    Tuesday, September 13, 2005 - The hydrolytic enzyme butylcholinesterase is correlated with lipid levels and may be useful in directing the treatment of hypertriglyceridemia in patients with Type 2 diabetes mellitus, Indian researchers suggest.
  • New SR-BI isoform found in atherosclerotic plaque
    Tuesday, September 13, 2005 - Swedish research appears to rule out a major role for the scavenger receptor class B type I in the pathophysiology of human atherosclerosis.
  • Soy protein protects against hepatic steatosis
    Tuesday, September 13, 2005 - Eating a soy-rich diet may help prevent the development of fatty liver in insulin-resistant individuals, animal study findings indicate.
  • ApoE linked to lobar intracerebral hemorrhage
    Monday, September 12, 2005 - US researchers have shed light on the pathophysiology of lobar intracerebral hemorrhage, with the discovery that a haplotype of the apolipoprotein E gene is associated with the condition.
  • Obesity boosts thromboembolism risk
    Monday, September 12, 2005 - Obesity is an independent risk factor for venous thromboembolism, results from a population-based study indicate.
  • Rosuvastatin effective in metabolic syndrome
    Monday, September 12, 2005 - Rosuvastatin appears to be more potent than atorvastatin in patients with the metabolic syndrome, study findings suggest, raising hopes of an improved approach to the treatment of this increasingly common condition.
  • HDL infusion shows anti-atheroma promise
    Friday, September 09, 2005 - A new approach to the treatment of atherosclerosis involving the infusion of small amounts of high-density lipoproteins has shown promise in animal studies, study results have shown.
  • HIV lipodystrophy therapy 'must be tailored'
    Friday, September 09, 2005 - Results of a study published this week reinforce the importance of individualized care in patients with HIV lipodystrophy, with the discovery that rosiglitazone and metformin have markedly different clinical effects.
  • No place for fish oil in arrhythmias
    Friday, September 09, 2005 - A major European trial has failed to demonstrate any benefit of fish oil supplements in patients at risk of arrhythmias and sudden death.
  • Dyslipidemia drugs are hitting the target
    Thursday, September 08, 2005 - More US patients than ever before are achieving target lipid levels through the use of lipid-lowering medications, suggest the results of a national survey into therapy compliance.
  • Mediterranean diet 'protects against high cholesterol'
    Thursday, September 08, 2005 - A study published this week lends further support to the putative health-giving properties of a Mediterranean diet, with the discovery that elderly Greek Cypriots have a reduced risk of hypercholesterolemia.
  • PON1 activity predicts vascular disease
    Thursday, September 08, 2005 - Differences in paraoxanase 1 activity may mediate the link between lipid/lipoprotein levels and vascular disease status, study results indicate.
  • Children using community health centers at high-risk of weight problems
    Wednesday, September 07, 2005 - Children who live in areas with less than comprehensive medical care, and who use community health care centers have a raised risk of obesity that may be even stronger than obesity-influencing factors such as ethnicity.
  • Education substantially alters lipid levels in Turkish women
    Wednesday, September 07, 2005 - Scientists have discovered that education level significantly alters high-density lipoprotein cholesterol level in Turkish women, and that university-level studies may confer a reduction in cardiovascular disease risk of up to 30%.
  • SREBP, SCAP interaction alters lipid levels in women
    Wednesday, September 07, 2005 - A study of individuals with familial hypercholesterolemia has revealed an interaction between genes for the sterol regulatory element-binding protein and the SREBP cleavage-activating protein that modulates lipid levels.
  • Crystallizing cholesterol 'cuts and tears plaque caps'
    Tuesday, September 06, 2005 - In vitro research suggests that the crystallization of cholesterol particles within atherosclerotic plaques promotes the erosion and rupture of plaque caps.
  • Exercise lipid benefits elucidated
    Tuesday, September 06, 2005 - Scientists reporting at the European Society of Cardiology 2005 Annual Congress believe they have found one of the ways by which exercise improves the lipid profile.
  • Rimonabant preserves large HDL cholesterol particles
    Tuesday, September 06, 2005 - The decrease in abdominal obesity induced by treatment with the cannabinoid receptor 1 antagonist rimonabant is accompanied by a maintenance of large high-density lipoprotein 2 cholesterol-like particles, analysis of results from the RIO-Lipids trial reveal.
  • HDL improves survival in STEMI, NSTEMI independently of LDL
    Monday, September 05, 2005 - Raised levels of high-density lipoprotein cholesterol improve short- and long-term survival in patients with ST-elevation myocardial infarction and non-ST elevation myocardial infarction, regardless of concentrations of low-density lipoprotein cholesterol, clinicians report.
  • Olive oil bite betrays NSAID properties
    Monday, September 05, 2005 - A chance observation that olive oil and ibuprofen sting the throat in the same way has led scientists to discover a non-steroidal anti-inflammatory compound within olive oil.
  • Statins rapidly restore endothelial function in childhood hypercholesterolemia
    Monday, September 05, 2005 - Besides its expected beneficial lipid effects, a month of statin treatment can also significantly improve endothelial function in children and adolescents with hypercholesterolemia, scientists say.
  • Adipose tissue metabolism disturbed in FCH
    Friday, September 02, 2005 - Dutch clinicians believe adipose tissue metabolism plays a part in the pathophysiology of familial combined hyperlipidemia, after showing that low levels of adiponectin contribute to the atherogenic lipid profile in patients with the condition.
  • OxLDL activates NFκB in angina patients
    Friday, September 02, 2005 - In patients with unstable angina, the activation of nuclear factor kB in monocytes is, at least partly, caused by molecules such as oxidized low-density lipoprotein cholesterol.
  • Six months of statins improves plaque stability, reduces plaque size
    Friday, September 02, 2005 - Statin therapy causes beneficial changes in plaque properties and volume after just 6 months, reveal results from a study that characterized plaques using intravascular ultrasound radio-frequency signal analysis.
  • Achilles tendon sonography accurately diagnoses FH
    Thursday, September 01, 2005 - Spanish scientists have recommended sonography of the Achilles tendon to differentiate familial from non-familial hypercholesterolemia.
  • ApoE gene modifies alcohol-stroke association
    Thursday, September 01, 2005 - A large study of older adults reveals a U-shaped relationship between alcohol intake and the risk of ischemic stroke that is significantly altered by apolipoprotein E genotype.
  • Lipid-lowering drugs cut death risk in elderly post revascularization
    Thursday, September 01, 2005 - Elderly patients who take cholesterol-lowering drugs after coronary revascularization enjoy a reduced risk of death and myocardial infarction, but are no less likely to require repeat revascularization procedures than those not taking these agents, results of a population-based study show.
  • ATP III revisions 'clinically useful' for risk stratification
    Wednesday, August 31, 2005 - Findings from a study of over 19,000 men support the inclusion of recent revisions to the National Cholesterol Education Programs Adult Treatment Panel III guidelines.
  • Early statin therapy reduces AMI death risk
    Wednesday, August 31, 2005 - Patients suffering acute myocardial infarction should be given statins within a day of hospitalization, say US clinicians after showing that treatment halves the risk of such patients dying in hospital.
  • Effects of NP's lipid mobilization properties outlined
    Wednesday, August 31, 2005 - Following evidence that natriuretic peptides can mobilize lipids, French scientists have reviewed the influences these factors may have on lipid disorders, obesity-related cardiovascular events, and cardiac cachexia.
  • Fat 'quality and quantity' determine CETP response to cholesterol
    Tuesday, August 30, 2005 - The ability of cholesterol to regulate the cholesterol ester transfer protein, and therefore the reverse cholesterol transport system, depends on the quantity and quality of fats ingested from the diet, animal studies reveal.
  • HL polymorphism influences lipid response to statin
    Tuesday, August 30, 2005 - Results from a multicenter study published in the journal Atherosclerosis show that a polymorphism of the hepatic lipase gene significantly modulates the effect pravastatin has on a patient’s lipid profile.
  • Newborn genetics affect maternal lipid profile
    Tuesday, August 30, 2005 - In what they believe to be the first study of its kind, Belgian clinicians have linked genetic polymorphisms in infants with the lipid profiles of their mothers.
  • HDL subspecies predict CVD risk better than HDL
    Friday, August 26, 2005 - Findings from the Veterans Affairs high-density lipoprotein cholesterol Intervention study show that, in patients with coronary heart disease, specific alterations in the HDL cholesterol subpopulation profile increase the risk of cardiovascular disease.
  • Olive oil benefits suppressed by cholesterol
    Friday, August 26, 2005 - Including olive oil in the diet, rather than adopting a complete Mediterranean-style diet, may be pointless, say scientists, after showing that cholesterol suppresses the beneficial effects of olive oil ingestion.
  • Statin-induced endothelial proliferation mechanism proposed
    Friday, August 26, 2005 - German clinicians have outlined a mechanism by which they believe statins inhibit the hypoxia-related proliferation of endothelial cells.
  • Canadian government funds raft of childhood obesity studies
    Thursday, August 25, 2005 - The Canadian government has pledged over 2.8 million Canadian dollars to fund a suite of studies into the causes of childhood obesity.
  • Childrens' TV 'dominated by high-fat food adverts'
    Thursday, August 25, 2005 - Television food advertisements are dominated by convenience products with high levels of fat and salt that lack fiber and important vitamins and minerals, findings published in the American Journal of Public Health indicate.
  • Chitosan weight-loss benefits 'product of poor data'
    Wednesday, August 24, 2005 - Researchers from New Zealand who performed a meta-analysis of trials into the use of chitosan say that the compound produces significantly greater weight loss than placebo, but attach important reservations to their results.
  • REVERSAL and TIMI trials 'significantly altered prescribing habits'
    Wednesday, August 24, 2005 - Study findings from Canada indicate that the publication of the REVERSAL and PROVE IT-TIMI 22 trials has significantly altered statin prescribing habits.
  • Triglycerides predict CVD in metabolic syndrome
    Wednesday, August 24, 2005 - In men with the metabolic syndrome, triglyceride concentrations accurately and independently predict the risk of cardiovascular disease, findings from a large-scale population-based study show.
  • Basis of berberine's anti-lipidemic effects elucidated
    Tuesday, August 23, 2005 - Scientists have shown that the ability of the herbal medicine berberine to reduce low-density lipoprotein cholesterol levels by stabilizing LDL receptor messenger RNA depends on the extracellular signal-regulated kinase.
  • Hyperthyroid resistin elevation does not affect BMI
    Tuesday, August 23, 2005 - Levels of the obesity-related hormone resistin are elevated in patients with hyperthyroidism, although this increase seems to have no effect on body weight or composition, clinicians report.
  • Scavenger receptor role in atherosclerosis questioned
    Tuesday, August 23, 2005 - The roles played by two macrophage receptors thought to mediate oxidized low-density lipoprotein cholesterol uptake need to be reassessed, say scientists, after showing that mice lacking the receptors still develop atherosclerotic lesions.
  • Increased weight offers AMI protection
    Monday, August 22, 2005 - Being overweight or obese seems to confer protection against death in the short-term in patients who suffer acute myocardial infarction, investigators from the Mayo Clinic in Rochester, Minnesota, USA, report.
  • PUFAs promote wound healing
    Monday, August 22, 2005 - Polyunsaturated fatty acids can promote the formation of collagen by fibroblasts and therefore speed wound healing, findings from an in vitro study show.
  • Saturated fat diet promotes arterial LDL uptake
    Monday, August 22, 2005 - A diet that has high levels of saturated fat promotes the selective uptake of low-density lipoprotein cholesterol into the arterial wall, an animal model of atherosclerosis indicates.
  • Grape extract improves lipid profile, reduces inflammation
    Friday, August 19, 2005 - Supplementation with lyophilized powdered grapes for just a month significantly improves lipid profile, and reduces levels of oxidative stressors and markers of inflammation, nutritional experts report.
  • Menstruation onset not linked with adult weight
    Friday, August 19, 2005 - Although increased weight can promote the start of puberty in girls, researchers have refuted the idea that the timing of a girl's first period, or menarche, is related to eventual adult weight.
  • Oxidized LDL receptor responsible for PPAR adipocyte lipid benefits
    Friday, August 19, 2005 - Scientists believe that the abilities of peroxisome-proliferator activated receptor-? ligands to regulate lipid metabolism and insulin sensitivity in adipocytes depend on increased expression of oxidized low-density lipoprotein receptor 1.
  • IL-6 'best inflammatory marker of atherosclerosis progression'
    Thursday, August 18, 2005 - Results of the long-term Edinburgh Artery Study show that interleukin-6 is the inflammatory marker that best predicts the progression of atherosclerosis.
  • Locus affecting HDL, LDL particle size discovered
    Thursday, August 18, 2005 - A quantitative-trait locus on chromosome one influences the size of high-density lipoprotein and low-density lipoprotein cholesterol particles, and might, therefore, affect susceptibility to coronary heart disease, scientists say.
  • SH2-B maintains body weight via leptin
    Thursday, August 18, 2005 - The JAK2-interacting protein SH2-B enhances sensitivity to leptin in mice and is necessary for normal energy metabolism and body weight maintenance, findings from a mouse model of obesity indicate.
  • Inflammation improvement after weight loss 'macrophage related'
    Wednesday, August 17, 2005 - French physicians report in the journal Diabetes that the improvement in inflammatory profile typical after weight loss is related to a reduction in macrophage number.
  • Liver type FABP reflects extent of diabetic nephropathy
    Wednesday, August 17, 2005 - In patients with Type 2 diabetes, concentrations of liver-type fatty-acid binding protein accurately reveal the extent of diabetic nephropathy, Japanese clinicians report.
  • NPC1L1 gene affects ezetimibe efficacy
    Wednesday, August 17, 2005 - Canadian investigators have shown that the NPC1L1 gene influences the change in low-density lipoprotein cholesterol induced by treatment with the cholesterol-absorption inhibitor ezetimibe.
  • IL-12 blockade 'promising therapy for atherosclerosis'
    Tuesday, August 16, 2005 - Inhibition of interleukin-12 by "vaccination" represents a "promising new strategy" to treat atherosclerosis in humans, findings from a Dutch animal study show.
  • Obese to lean switch before teens normalizes BP
    Tuesday, August 16, 2005 - Researchers have underlined the importance of anti-obesity programs for children, after showing that obese children whose weight normalized by the age of 14 years enjoy normal blood pressure in adulthood.
  • Totally robotic gastric bypass procedure described
    Tuesday, August 16, 2005 - In what they believe is a surgical first, researchers in the USA have described a totally robotic, laparoscopic, Roux-en-Y gastric bypass procedure, which they say is superior to standard bypass surgery for treating obesity.
  • CRP formation explains varying vascular actions
    Monday, August 15, 2005 - The seemingly contradictory pro-atherogenic yet vasoprotective properties of C-reactive protein are due to the different configurations the protein can take on, an animal study reported in the journal Circulation indicates.
  • Loci determining lipid profile in atherogenic dyslipidemia identified
    Monday, August 15, 2005 - A study into families with atherogenic dyslipidemia has pinpointed several quantitative-trait loci that influence lipid profile, say researchers, in findings that should inform investigations into the genes responsible for lipid phenotypes.
  • Parental lifestyle influences childhood obesity risk
    Monday, August 15, 2005 - A large-scale study into how parents influence their children's weight shows that passing on bad eating habits and not discouraging a sedentary lifestyle makes children 33% more likely to become obese as young adults.
  • Adiponectin influences childhood insulin sensitivity
    Friday, August 12, 2005 - Adiponectin improves insulin sensitivity from a young age, but, in contrast to previous suggestions, has no impact on the vascular changes seen in early atherosclerosis, British scientists say.
  • Dyslipoproteinemia linked with VT
    Friday, August 12, 2005 - US researchers have linked dyslipoproteinemia with venous thrombosis, an association they believe may be due to differences in the cholesteryl ester transfer protein.
  • SR-BI separates apo catabolism
    Friday, August 12, 2005 - Processing by the scavenger receptor class ? type I segregates the catabolism of apolipoprotein A-I and A-II, results of an animal study published in the Journal of Lipid Research show.
  • Common POMC variants predict body fat distribution
    Thursday, August 11, 2005 - Common variants in the pro-opiomelanocortin gene influence body fat distribution and may play a role in metabolic regulation, UK researchers report.
  • Leptin expression explains reduced lipogenesis in old age
    Thursday, August 11, 2005 - The decrease in expression of the sterol regulatory-element binding protein gene and reduced lipogenic activity that occurs in white adipose tissue with aging may be due to an increase in expression of the leptin, animal research reveals.
  • Statins pre-PCI reduce nephropathy risk
    Thursday, August 11, 2005 - North American physicians have stressed the need for statin therapy prior to percutaneous coronary intervention, after demonstrating that the drugs significantly reduce the risk of contrast-induced nephropathy.
  • Adipose macrophage content 'weakly linked with BMI'
    Wednesday, August 10, 2005 - The presence of macrophages in adipose tissue is correlated only weakly with body mass index but strongly with insulin sensitivity, study findings reported in the journal Diabetes indicate.
  • Race predicts triglyceride levels independently of BMI
    Wednesday, August 10, 2005 - Ethnicity strongly predicts levels of plasma triglycerides and sex hormones in pre-menopausal women, independently of body mass index, study findings show.
  • Streamlined fatty acid quantification 'makes larger studies possible'
    Wednesday, August 10, 2005 - Scientists have described a simplified method for analyzing fatty acid methyl esters that they believe will make large-scale population-based nutritional analyses possible.
  • Chemokine receptors play 'differential roles' in atherosclerosis
    Tuesday, August 09, 2005 - Animal studies into the function of the chemokine receptors CCR2 and CXCR3 indicate that they have differential effects in the development of atherosclerosis, and show that T lymphocytes play a key role in the initial stages of the disease.
  • Injecting insulin into lipohypertrophic sites 'should be avoided'
    Tuesday, August 09, 2005 - Swedish physicians have warned against injecting insulin aspart into lipohypertrophic sites, after demonstrating that the practice can reduce the maximum amount of insulin that reaches a patient's plasma by a quarter.
  • Tendon xanthomatosis due to decreased HDL3-mediated cholesterol efflux
    Tuesday, August 09, 2005 - A case report of a family with novel massive tendon xanthomatosis indicates that this condition arises because of decreased high-density lipoprotein 3-mediated cholesterol efflux.
  • Aerobic exercise reduces triglyceride levels
    Monday, August 08, 2005 - Aerobic exercise significantly decreases triglyceride levels in overweight and obese adults, results from a meta-analysis published in the International Journal of Obesity indicate.
  • Dyslipidemias in obese children common in absence of hypertension
    Monday, August 08, 2005 - A study of overweight children supports recent recommendations to test for dyslipidemia in all children with weight problems, rather than just those who are both overweight and hypertensive.
  • Factor behind statin endothelial benefits revealed
    Monday, August 08, 2005 - American clinicians believe they have found the transcription factor that mediates the beneficial endothelial effects of the statin class of drugs.
  • LCAT promising CVD target
    Friday, August 05, 2005 - The lecithin:cholesterol acyltransferase gene is a promising target for raising levels of high-density lipoprotein cholesterol and preventing cardiovascular disease, Dutch researchers report in an early online edition of the journal Circulation.
  • Satiety signal sensitivity reduced by high-fat diet
    Friday, August 05, 2005 - Rats fed a high-fat diet become insensitive to the appetite-suppressing hormone cholecystokinin, leading to short-term overconsumption, scientists from the Pennsylvania State University in Philadelphia, USA report.
  • Sphingomyelinase promotes lipoprotein aggregation
    Friday, August 05, 2005 - Sphingomyelinase promotes the aggregation of small very low-density lipoprotein and intermediate-density lipoprotein cholesterol particles, as well as enhancing their ability to adhere to arteries, Finnish clinicians report.
  • Apo(a) may inhibit hepatic lipid remnant clearance
    Thursday, August 04, 2005 - Animal studies carried out at Columbia University in New York, USA may explain the increased atherosclerosis seen in patients whose secretion of apolipoprotein a is raised.
  • Immediate statin therapy beneficial in acute cerebrovascular disorders
    Thursday, August 04, 2005 - Scientists have demonstrated that immediate statin therapy has clinical benefits in acute cerebrovascular disorder, in what is thought to be the first study of its kind.
  • Leptin promotes atherosclerosis and cardiovascular disease
    Thursday, August 04, 2005 - Leptin promotes atherosclerosis and raises the risk of cardiovascular disease, according to the results of a study published in the journal Arteriosclerosis, Thrombosis, and Vascular Biology.
  • LDL receptor is 'useful marker' of acute coronary syndrome
    Wednesday, August 03, 2005 - Japanese study findings confirm that serum levels of the soluble form of lectin-like oxidized low-density lipoprotein receptor-1 provide a useful indicator for the early diagnosis of an acute coronary syndrome.
  • Perilipin and cholesterol genes promote plaque cholesterol storage
    Wednesday, August 03, 2005 - Overexpression of perilipin and co-ordinated modifications of the key regulatory factors for cholesterol metabolism could favor cholesterol accumulation and thus promote atheroma development, report researchers.
  • Waist circumference linked to childhood metabolic syndrome
    Wednesday, August 03, 2005 - Waist circumference measurements in children can provide a useful gauge of future susceptibility to Type 2 diabetes mellitus and cardiovascular disease, report Argentinean investigators.
  • Overproduction of VLDL particles in diabetics driven by hyperglycemia
    Tuesday, August 02, 2005 - Study findings suggest that the overproduction of hepatic very-low-density lipoprotein particles in patients with Type 2 diabetes may be due to hyperglycemia.
  • Statins reduce ischemic stroke mortality risk
    Tuesday, August 02, 2005 - As predicted by animal research, statin use is associated with decreased mortality in patients who suffer ischemic stroke, say scientists who call for prospective studies of this protective effect.
  • Testing for RLPs over triglycerides for CHD prediction not recommended
    Tuesday, August 02, 2005 - Researchers have found that remnant-like particles do not appear to predict coronary heart disease risk beyond that detected using measures of triglyceride levels.
  • Age-related cerebral blood flow decline 'not reduced by pravastatin'
    Monday, August 01, 2005 - In contrast with promising animal studies, a sub-study of participants from the PROSPER trial suggests that pravastatin does not retard the decrease in cerebral blood flow associated with aging.
  • Lipid droplet growth 'independent of triglyceride synthesis'
    Monday, August 01, 2005 - In what is believed to be the first study of its kind, scientists have shown that lipid droplets can increase in size without triglyceride biosynthesis by a process involving microtubules.
  • Metabolic syndrome predicts atherosclerosis in young adults
    Monday, August 01, 2005 - Physicians in the USA have recommended early screening and treatment for the metabolic syndrome to prevent cardiovascular disease, after showing that the presence of the syndrome is significantly associated with increased atherosclerotic burden.
  • Adiponectin signaling linked to obesity, insulin resistance
    Friday, July 29, 2005 - Research into the adiponectin receptor 1 has revealed a novel mechanism linking skeletal muscle adiponectin signaling with central obesity and insulin resistance, British scientists report.
  • Lipoteichoic acid explains cardiac bacterial sepsis
    Friday, July 29, 2005 - Research in animals has enabled scientists to outline a mechanism by which lipoteichoic acid might cause the cardiovascular abnormalities associated with gram-positive sepsis in humans.
  • Recall alert over fake statin discovery
    Friday, July 29, 2005 - A batch of counterfeit atorvastatin has been found in the UK pharmaceutical supply chain, prompting a recall by the health regulators and the drug's maker.
  • Non-HDL powerful CHD risk predictor in diabetes
    Thursday, July 28, 2005 - In patients with diabetes, levels of non-high-density lipoprotein cholesterol predict the risk of death from coronary heart disease better than concentrations of low-density lipoprotein cholesterol, study findings show.
  • Statins protect against pneumonia death
    Thursday, July 28, 2005 - Statin therapy reduces the risk of dying from pneumonia via a mechanism that is not understood but which researchers say deserves further study.
  • Weight loss tempers post-MI diabetes risk
    Thursday, July 28, 2005 - Patients who survive a myocardial infarction and have diabetes or the metabolic syndrome have a raised risk of recurrent cardiovascular events and death that can be significantly blunted by weight loss, analysis of participants in the GISSI-Prevenzione trial shows.
  • Gut hormone injections aid weight loss in obese
    Wednesday, July 27, 2005 - Self-administered injections of the gut hormone oxyntomodulin reduces appetite and may promote weight loss in individuals with obesity, study findings published in the journal Diabetes show.
  • OxLDL predicts CHD in healthy men
    Wednesday, July 27, 2005 - Oxidized low-density lipoprotein cholesterol is a promising marker for coronary heart disease in healthy individuals, say a group of scientists who recommend further study into the predictive value of the lipoprotein.
  • Political policies reduce Polish fat intake
    Wednesday, July 27, 2005 - Government policies influencing the amount and type of fat eaten have led to a rapid decline in mortality from coronary heart disease in Poland, researchers report.
  • Fatness more than fitness determines lipid profile in youth
    Tuesday, July 26, 2005 - Clinicians have reinforced the importance of maintaining a healthy weight in childhood, after showing that body fat levels in teenagers are strongly linked to lipid metabolism and future risk of cardiovascular disease.
  • Lipid response to diet genetically determined
    Tuesday, July 26, 2005 - The changes in lipid profile brought about by replacing fat in the diet with carbohydrates are mostly determined by genetics, findings from a study of twins show.
  • Statins first effective therapy in diastolic HF
    Tuesday, July 26, 2005 - Statins may represent the first therapy to reduce mortality in patients with diastolic heart failure, US scientists report in the journal Circulation.
  • Insulin role in hepatic fat regulation revealed
    Monday, July 25, 2005 - Animal research has identified a new mechanism by which hepatic fat metabolism is regulated by insulin's actions on fatty acid synthase that could lead to a novel human treatment for hepatic lipidemia in diabetes.
  • Polymorphism increases adipocyte ß2-adrenoceptor function
    Monday, July 25, 2005 - Researchers have found a common variation in a gene thought to regulate body fat levels and insulin sensitivity that markedly increases ß2-adrenoceptor activity in subcutaneous fat cells.
  • Tendon xanthomas independently linked with CVD risk
    Monday, July 25, 2005 - Scientists have shown an association between tendon xanthomas (TXs) in individuals with familial hypercholesterolemia (FH) and a raised risk of cardiovascular disease (CVD), independent of the presence of a low-density lipoprotein receptor gene mutation.
  • Missing obesity, diabetes link is adipocyte-derived
    Friday, July 22, 2005 - The adipocyte-derived retinol-binding protein-4 may mediate the link between obesity and Type 2 diabetes, say researchers who showed that raised levels of this protein promote insulin resistance.
  • PPAR agonist raises apoA-V levels
    Friday, July 22, 2005 - Scientists have shown that the peroxisome proliferator-activated receptor a can increase circulating levels of apolipoprotein A-V in primates, suggesting that apoA-V measurement could be used in the development of drugs to treat human dyslipidemia.
  • Statins started too late in diabetic dialysis patients
    Friday, July 22, 2005 - Tardy initiation of statin therapy in patients with Type 2 diabetes who are on dialysis may eliminate the cardiovascular benefits associated with the treatment in this high-risk population, researchers believe.
  • BMI link with CV risk in rehab reported
    Thursday, July 21, 2005 - Obese individuals are more than twice as likely as their normal weight counterparts to experience non-fatal cardiac events following cardiac rehabilitation, although body mass index is inversely associated with cardiovascular mortality, researchers report.
  • Mechanisms behind HDL's plaque benefits revealed
    Thursday, July 21, 2005 - Results from an ultrasound study reveal the mechanisms by which high-density lipoprotein cholesterol stabilizes atherosclerotic plaques and retards their progression.
  • Pleiotropic statin benefits via PUFA formation
    Thursday, July 21, 2005 - The pleiotropic benefits associated with statin therapy may be mediated by an increased formation of long-chain polyunsaturated fatty acids and their metabolites, Finnish clinicians believe.
  • Best lipid CVD risk predictors outlined
    Wednesday, July 20, 2005 - North-American clinicians report in the Journal of the American Medical Association that they have cleared up some of the confusion over which lipid measures best reflect cardiovascular disease risk.